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Hello I have solved my problem, yesterday I started to play and then I only deactivated the construction simulation and the delivery of materials and my game runs perfectly, in case someone else has this problem do not activate the debug mode of the game just remove the simulation and your game will run perfectly, I also solved my mods I had too much and investigate that the game only recognizes 150 companies among airlines, businesses etc. thank you very much for your help a 100 for those who helped me solve my problem God bless you
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We are happy to help with any problems that come across! 
I am glad you have solved both of your problems, that first one was really unique. I have never heard of it, so it was fun to find out how it was resolved. Of course it will need some fixing, but if it works in the meantime it should be all good.
PS: I am quite foolish, I should have thought about the amount of mods, a good lesson for me really. 
Don worry
I am glad to hear that the problem have been resoved 
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