Ok strange. Best is to start with all Default active any then maybe only one mod to see if it works then.
When you unsubscribe mods, check also if the folders get removed at your Steam directory on Windows:
\steamapps\workshop\content[game number]
Every mod creates a folder there. This one should get removed atomatically when you unsubscribe.
If it’s empty already but you subscribed to tons of mods, then you may have a sync problem.